Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance

Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments.In this study,we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance model.We established a model of sleep rhythm disturbance in C57 BL/6 J mice via a sleep deprivation method involving manual cage tapping,cage jostling,and nest disturbance.We used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive function.Our results indicated that an intervention in which the mice were exposed to blue light(40-Hz flickering frequency)for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep deprivation.However,interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points,as well as 2 Hz-blue light at 3 intervention time points(subjective day time,subjective night time,and offset time points),had no positive effects on circadian rhythm shift or memory deficits.Additionally,a 2000-Hz sound intervention during subjective day time attenuated the24-hour-acrophase shift and memory decline,while 440-Hz and 4000-Hz sounds had no effect on circadian rhythms.Overall,these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake rhythm.All animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University,China(approval No.20171102)on November20,2017.     

浙江省2007－2017年罕见病住院病例特征分析

目的 分析2007-2017年浙江省24 388例罕见病住院病例特征，为制定罕见病防控策略提供依据。方法 收集2007-2017年浙江省10家三级甲等（三甲）医院罕见病住院病例资料和各年度住院数，进行描述性统计分析。结果 罕见病病例共24 388例，占住院总例数的2.69‰（24 388/9 054 201），病例数居前3位的疾病类型依次为"血液和造血器官疾病以及某些涉及免疫机能的异常"（占32.81%，8 001/24 388）、"先天性畸形、变形和染色体异常"（占24.87%，6 065/24 388）和"神经系统疾病"（占19.01%，4 635/24 388）；2007-2017年罕见病病例数呈逐年增长趋势，年均增幅19.69%，而罕见病例数占同期住院总例数比例仅在2016-2017年明显上升，各类型罕见病时间分布呈不同特征；罕见病的病例数男女性别比为1.35：1（13 990/10 398），男女性别比最高的3类疾病依次为"消化系统疾病"（4.45：1，1 180/265）、"损伤、中毒和外因的某些其他后果"（3.51：1，281/80）和"神经系统疾病"（2.26：1，3 213/1 422）；各年龄段罕见病类型、各类型罕见病年龄分布均呈不同特征；病例数居前10位的疾病占全部罕见病例数的53.55%（13 060/24 388），其中前3位疾病分别为成人粒细胞缺乏症（14.41%，3 515/24 388）、皮质基底核退化症（7.60%，1 854/24 388）和亨诺克-舍恩莱因紫癜（6.01%，1 466/24 388）。结论 本研究分析的浙江省2007-2017年24 388例罕见病住院病例的特征资料，是推动我国罕见病的研究、监测或登记数据库构建、制定防控策略的参考依据。     

Correction to: The IgG galactosylation ratio is higher in spondyloarthritis patients and associated with the MRI score

Clinical Rheumatology - In the original version of the above article the References 19 and 20 were incorrect which cannot describe the development of the SPARCC score.     

西部单中心51例套细胞淋巴瘤患者临床特征及预后因素分析

目的:研究套细胞淋巴瘤（MCL)患者的临床特点及预后相关因素，进一步全面评估病情，探索个体化治疗。方法:回顾性分析2012年1 月至2016年12 月经我院病理科确诊的51例MCL 患者的临床特点、住院20例患者的预后分层和不同化疗方案的近期及远期疗效，并进行随访观察。结果:20例住院治疗患者中，R-Hyper-CVAD组及R-CHOP样组的ORR（分别为100%、100%）均高于其未联合美罗华组（分别为50%、40%）；MIPI评分中，低危组ORR为75.0%，明显高于中危组（16.6%）；CD5-患者CR、PR均高于CD5+患者；Ki67≥30%患者CR率（20%）大于Ki67＜30%组（11%），PR率则相反；Ki67＜30%患者3年OS明显高于Ki67≥30%患者，有统计学差异，而PFS无统计学差异；MIPI分组中，低危组3年OS明显高于中高危组，有统计学差异，PFS无统计学差异；美罗华组无论OS还是PFS均高于非美罗华组；Hyper-CVAD组与非Hyper-CVAD组OS、PFS均无统计学差异。结论:美罗华联合化疗治疗MCL的疗效是肯定的，绝大多数患者能够耐受减低剂量的Hyper-CVAD A及B方案化疗，但统计学显示与非Hyper-CVAD组无明显差异，可能与病例数偏少相关，需要更多大样本的循证医学的支持。